NSC 612049
《英文MSH詞典》NSC 612049
[入口詞] NSC 612049
[主題詞] Didanosine
[藥動學] Reverse Transcriptase Inhibitors
[英文釋義] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication,acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate,its putative active metabolite.